2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1901):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-177371
    CEBPA-51 saRNA
    CEBPA-51 saRNA, a double-stranded RNA oligo duplex to specifically upregulate the transcription of the CEBPA gene. CEBPA-51 saRNA contains multiple 2′-O-methyl modified bases to prevent nonspecific immunostimulatory activity.
    CEBPA-51 saRNA
  • HY-10821R
    Raltitrexed (Standard)
    		Inhibitor
    Raltitrexed (Standard) is the analytical standard of Raltitrexed. This product is intended for research and analytical applications. Raltitrexed is an antimetabolite agent used in chemotherapy, acting by inhibiting thymidylate synthase.
    Raltitrexed (Standard)
  • HY-W553730
    2’-Deoxy-2’-iodouridine; 2’-Iodo-2’-deoxyuridine
    2’-Deoxy-2’-iodouridine; 2’-Iodo-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-2’-iodouridine; 2’-Iodo-2’-deoxyuridine
  • HY-B0277R
    Vidarabine (Standard)
    		Inhibitor
    Vidarabine (Standard) is the analytical standard of Vidarabine. This product is intended for research and analytical applications. Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses. Vidarabine has IC50s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2. Vidarabine also has anti-orthopoxvirus activity.
    Vidarabine (Standard)
  • HY-N0157AR
    Orotic acid zinc (Standard)
    		Chemical
    Orotic acid (zinc) (Standard) is the analytical standard of Orotic acid (zinc). This product is intended for research and analytical applications. Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats.
    Orotic acid zinc (Standard)
  • HY-171520
    2'-O-MOE-GMP
    2'-O-MOE-GMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-O-MOE-GMP
  • HY-154274
    5-Cyanouridine
    5-Cyanouridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    5-Cyanouridine
  • HY-W653970
    5-Azacytidine-15N4
    5-Azacytidine-15N4 is 13C and 15N labeled 5-Azacytidine. 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy.
    5-Azacytidine-<sup>15</sup>N<sub>4</sub>
  • HY-134273A
    8-Br-dGTP sodium
    8-Br-dGTP (8-Bromo-dGTP) sodium (Compound 5), an 8-brominated purine nucleotide, is a syn-oriented analog of dGTP. 8-Br-dGTP sodium can be hydrolyzed by the enzyme hMTH1 protein (HY-P74740). 8-Br-dGTP sodium inhibits dGTP-activated ADP reduction with a Ki of 56  μM. 8-Br-dGTP sodium has no significant genotoxicity and mutagenic potentials during DNA synthesis.
    8-Br-dGTP sodium
  • HY-134246
    7-CH-5'-dAMP
    7-CH-5'-dAMP (5'-dTuMP) is an adenylate derivative that acts as a potential substrate, competitive inhibitor, or modulator of enzymes that interact with 2-deoxyadenosine-5-monophosphate.
    7-CH-5'-dAMP
  • HY-171528
    2′-OMe-GDP
    2′-OMe-GDP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-OMe-GDP
  • HY-47272A
    N6-Benzoyl-9-β-D-arabinofuranosyladenine hydrate
    N6-Benzoyl-9-β-D-arabinofuranosyladenine hydrate is the hydrate of N6-Benzoyl-9-β-D-arabinofuranosyladenine (HY-47272). N6-Benzoyl-9-β-D-arabinofuranosyladenine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N6-Benzoyl-9-β-D-arabinofuranosyladenine hydrate
  • HY-B1449S12
    Uridine-d12
    Uridine-d12 (β-Uridine-d12) is the deuterium labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond.
    Uridine-d<sub>12</sub>
  • HY-W779021
    Adenosine-15N
    		Chemical
    Adenosine-15N (Adenine riboside-15N) is 15N labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
    Adenosine-<sup>15</sup>N
  • HY-W048494
    N4-Bz-5-Me-DMT-2'-O-MOE-Cr
    N4-Bz-5-Me-DMT-2'-O-MOE-Cr (N4-Benzoyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine) is a nucleoside analog containing a dimethoxytrityl (DMT) group, commonly used in the synthesis of nucleic acids.
    N4-Bz-5-Me-DMT-2'-O-MOE-Cr
  • HY-W338294
    2'-Deoxycytidine hydrate
    2'-Deoxycytidine (Deoxycytidine) hydrate is a building block of nucleic acid.
    2'-Deoxycytidine hydrate
  • HY-W011526
    2-Amino-2'-fluoro-2'-deoxyadenosine
    2-Amino-2'-fluoro-2'-deoxyadenosine is a building block of nucleic acid.
    2-Amino-2'-fluoro-2'-deoxyadenosine
  • HY-171513
    2'-F-AMP
    2'-F-AMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-F-AMP
  • HY-171515
    2'-F-UMP
    2'-F-UMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-F-UMP
  • HY-171524
    2'-F-ADP
    2'-F-ADP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-F-ADP